"NEW WAYS TO HEAL FRACTURES ENTER MARKET IN THE WORKS"

ORTHOPEDICS TODAY 16(l)

ARTICLE REVIEW

PAUL MCNALLY, D.O., Resident, Orthopaedic Surgery

FREEMAN MILLER, M.D. Attending Pediatric Orthopaedic Surgeon

CLINICAL CASE PRESENTATION

ORTHOPAEDIC DEPARTMENT

THE ALFRED I. DUPONT INSTITUTE

WILMINGTON, DELAWARE

GENERAL INFORMATION:

TWO WAYS OF AIDING HEALING:

  1. Osteoconduction - product supports the ingrowth of capillaries, perivascular tissues, and osteoprogenitor cells from a host into an implant or graft
  2. Osteoinduction - elicits mesenchymal stem cells from the surrounding area that differentiate into osteoblasts -ideal product: combination of osteoconductive material and osteoinductive agent
NEW BONE GRAFTS:
  1. Pro Osteon -
  2. Bioglass US Biomaterials Corp,
  3. Collagraft Zimmer
  4. Grafton Osteotech
EXPERIMENTAL PRODUCTS: (AWAITING FDA APPROVAL)
  1. Norian Skeletal Repair System (SRS)
  2. Bone Source Hydroxyapatite Cement -(Developmental)
  3. Transforming Growth Factor-Beta One (TGF-Bl)
  4. OP-1 - (currently in clinical trials)
  5. BMP-2 - (human clinical trials)